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A critical hurdle in the management of GLP-1 therapies is the high rate of discontinuation

Combining crystallography, spectroscopy and extensive mechanistic analysis, we show here that the CstB-specific loop in the PDO domain positions the S atom of a C201-G202 glutathione mimic 3.4 away from the Fe(II) center, which when persulfidated, becomes the substrate for Fe(II)- and O 2 -dependent self S -sulfonation

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Freezing : A frozen pen should never be used, regardless of how it looks once thawed

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